CKO diminished the population of CD45+CD11c+F4/80+CD206+CD86− M2 macrophages, while it increased CD45+CD11c+F4/80+CD206−CD86+ M1 macrophages and CD45+CD3+CD4−CD8+ cytotoxic T cells infiltrating the tumor (Fig. 9d–h). The gene discussed is CD86; the disease is neoplasm.