UPF1, a key factor in NMD, UPF1-dependent mRNA decay (UMD) and numerous other posttranscriptional regulation pathways, and it regulates the abundance of lncRNAs and protein-coding mRNAs to determine cell fate or maintain cell homeostasis; some UPF1-bound lncRNAs are involved in tumorigenesis and cancer progression15,37–40. This evidence concerns the gene UPF1 and cancer.