Marco-Benedi et al.3 report that in HeFH, Lp(a) concentration appears to depend on the gene causing FH: mean Lp(a) level was found to be 36.5 mg/dL in APOB-dependent FH but 21.7 mg/dL in LDLR-dependent FH; however, in LDLR-dependent FH, Lp(a) levels did not vary between protein domains, and the higher Lp(a) in HeFH is not explained by higher LDL. Here, LDLR is linked to familial hyperaldosteronism.