Haploinsufficiency of MBD5 causes diverse phenotypes which include hyperphagia, behavioural problems, craniofacial abnormalities, language impairment, microcephaly, development and motor delay, short stature, sleep disturbance, epilepsy, hyperphagia, obesity, and seizures [17–26]. This evidence concerns the gene MBD5 and obesity due to melanocortin 4 receptor deficiency.