SMAD2 and Hepatic fibrosis: However, there are still few studies on the performance of Robo2 in liver fibrosis, for example, Zeng et al. clarify that Slit2/Robo2 mediates the occurrence of liver fibrosis and regulates the biological behavior of hepatic stellate cells (HSCs) by motivating PI3K/Akt signaling pathway12; soluble triggering receptor expressed on myeloid cells-1 (STREM-1)/Robo2 can promote the activation of HSCs and liver fibrosis through PI3K/Akt and Smad2/3 signaling pathways13.