To test this conjecture, we first searched the GEPIA database for expression correlations between FBXO22 and the reported Rad51 transcription factors (including FOXM1, TP53, E2F1, E2F4, E2F7, EGR1, CDK12, and CDK13) in lung adenocarcinoma and found that FOXM1 correlated most strongly with FBXO22 (R = 0.34, P < 0.001) (Fig. 5A and Fig. S3). This evidence concerns the gene E2F4 and lung adenocarcinoma.