CD4 and systemic sclerosis: The cell-type-based partitioned heritability of active histone marks, H3K9ac, H3K27ac, H3K4me3, and H3K4me1, showed that H3K4me1, one of the enhancer-related histone marks, was significantly and highly enriched in primary CD19+ B cells followed by CD4+ effector T cells in Japanese SSc (Supplementary Data 25).