As expected, significant enrichment and a high proportion of overlapping annotated genes were observed in the SLE-related pathway followed by various immune-related pathways, such as the butyrophilin-related pathway, IL-20 family signaling, Fc γ receptor-mediated phagocytosis, adaptive immune system, JAK-STAT signaling pathway, or IFN-γ pathway (Supplementary Data 10). This evidence concerns the gene IFNG and systemic lupus erythematosus.