Detailed analyses of lung histology demonstrated a nearly 8-fold reduction in the overall number, individual size and overall area of metastatic foci in PyMT;Smyd2 vs PyMT control (Fig. 1i–k), and we observed elevated SMYD2 expression in PyMT tumor biopsies obtained from lung metastasis vs primary site (Supplementary Fig. S1k). This evidence concerns the gene SMYD2 and neoplasm.