NLRP3 and COVID-19: In COVID-19, the degree of inflammasome activation, particularly of the NLR family pyrin domain containing 3 (NLRP3) inflammasome, correlates with disease severity, and analysis of post-mortem lung biopsies from patients with fatal COVID-19 shows that the inflammasome complex is highly activated compared to healthy controls or patients who died from influenza12,13.