Given that the demethylase activity of KDM1A is vital for its participating in various diseases such as lung adenocarcinoma and acute myeloid leukemia, we sought to investigate whether the enzymatic activity of KDM1A is indispensable for its pivotal role in the development of NAFLD (29, 30, 31, 32). Here, MBD2 is linked to acute myeloid leukemia.