In this study, we found that Kdm1a deficiency in the context of NAFLD improved hepatic steatosis by primarily inhibiting the expression of lipogenesis and fatty acid uptake genes, such as Scd1, Cd36, Plin2, and Fabp1. Furthermore, Kdm1a deficiency in the context of NAFLD also suppressed the expression of several inflammatory genes, such as Tnfα and interleukin-1β, to ameliorate inflammation. Here, PLIN2 is linked to fatty liver disease.