In LPS-induced acute lung injury (ALI), IFNγ exacerbates pathogenesis.49 It is thus conceivable that dysregulated N(IFNγ) could also lead to organ damage Recent studies have shown that during SARS-CoV2 infection, a dysregulated IFNγ-neutrophil axis is associated with mortality and cytokine storm50, 51. The gene discussed is IFNG; the disease is acute respiratory distress syndrome.