Kwangsik Nho et al. measured the markers of liver function in serum and the cognitive performance and AD pathological features of 1174 AD patients and 407 normal elderly people, and they found a strong correlation between AD diagnosis and an increased ratio of alanine transaminase (ALT) to aspartate transaminase (AST), both of which are markers of liver function in serum [8]. This evidence concerns the gene GPT and Alzheimer disease.