AIF1 and neoplasm: Similarly, cells double-labeled with Iba1 and vimentin (interpreted as activated macrophages or microglial cells (71, 74, 127)) may represent a smoldering status of immune activation that could have clinical relevance in these tumors, and cells double-labeled with Iba1 and GFAP may represent an increase in the number of phagocytic macrophages/microglia, or possibly an increase in tumor cells with phagocytic properties with increased invasive ability (74, 78, 79) (138–140).