The second cell population might be a cell population found in diseased states such as stroke and neurodegenerative states (76, 77, 122) and recently found to be present in glioblastoma (79), in which cells share the molecular signatures of both Iba1 expressing cells (macrophages or microglia) and GFAP expressing cells (astrocytes or tumor cells) (75, 79). The gene discussed is AIF1; the disease is glioblastoma.