IRF3 and Flavivirus Infections: Combined, our above data argue that neither G3BP proteins nor G3BP1 complexes (SGs or RLBs) alter the activation of the RLR-MAVS-IRF3, OAS/RNase L, or PKR innate immune pathways in response to dsRNA lipofection or flavivirus infection, which contrasts with previous studies (18–24, 36).