ACE2 and infection: For example, direct infection by SARS-CoV-2 via ACE2-dependent pathways correlates with mitochondrial dysfunction [92], and there is a close association between mitochondrial dysfunction and immunosenescence; this may lead to an increased possibility of imbalance in the immune response to SARS-CoV-2 and may manifest as an exaggerated proinflammatory response and a cytokine storm [93], resulting in further multiorgan damage.