In clinical normal patients (n = 14 patients, 1 tissue/patient) (SI Appendix, Fig. S1 C1) or benign-tumor tissues (n = 126 patients, 1 tissue/patient) (SI Appendix, Fig. S1 C2 and Dataset S1), there are very low PMCA2 signals and no CC/CCTs, indicating that normal tissues and benign-tumor tissues don’t generate CCs/CCTs and that PMCA2 expression is tightly controlled and maintained at low abundance in both normal human tissues and benign tumors (SI Appendix, Fig. S1 C1 and C2). Here, ATP2B2 is linked to benign neoplasm.