ATP2B2 and neoplasm: In clinical normal patients (n = 14 patients, 1 tissue/patient) (SI Appendix, Fig. S1 C1) or benign-tumor tissues (n = 126 patients, 1 tissue/patient) (SI Appendix, Fig. S1 C2 and Dataset S1), there are very low PMCA2 signals and no CC/CCTs, indicating that normal tissues and benign-tumor tissues don’t generate CCs/CCTs and that PMCA2 expression is tightly controlled and maintained at low abundance in both normal human tissues and benign tumors (SI Appendix, Fig. S1 C1 and C2).