All viral infection datasets showed significant increase in ISG expression (p adj < 0.001), whereas Arenaviridae, Coronaviridae, Filoviridae, and Orthomyxoviridae infections demonstrated significant downregulation of major histocompatibility complex (MHC) class II genes (p adj < 0.05) and significant upregulation of MS1 signature genes (p adj < 0.01; Figures S3A, S3B, S3C, and Table S2).10 Here, HLA-C is linked to viral infectious disease.