Table 2 (also see Multimedia Appendix 2) presents the results for the independent associations between Lp(a), UACR, and CKD risk. The high Lp(a) group showed a nonsignificant association with an elevated CKD risk (HR 1.05, 95% CI 0.98-1.13; P=.16) compared with the low Lp(a) group. By contrast, the high-normal UACR group was significantly associated with a 20% increased risk of CKD compared with the low-normal UACR group (HR 1.20, 95% CI 1.13-1.27; P<.001). Similar results were observed when treating Lp(a) and UACR as continuous variables (see Table S4 in Multimedia Appendix 1). This evidence concerns the gene LPA and chronic kidney disease.