While the FIB-4 is certainly not a perfect index, it is widely adopted to exclude the presence of advanced liver disease in the general population due to its ease of calculation and interpretation.25,26 The FIB-4 score also adds specificity to the alternative of using AST or ALT levels alone, since patients with even advanced liver disease often have laboratory values within the reference ranges.27 The gene discussed is GPT; the disease is liver disorder.