Previous studies have suggested the potential involvement of Sox6 in the EMT of numerous tumor cells, engaging various downstream pathways/factors, including Twist1 (Wang et al. 2018), the Akt pathway (Jiang et al. 2018), and the Wnt/β-catenin pathway (Iguchi et al. 2007; Dong et al. 2018). This evidence concerns the gene AKT1 and neoplasm.