The intraperitoneal injection of D-Gal along with OVX caused a prominent elevation in the hippocampal levels of Tau (3.5-fold) and Aβ42 (2.3-fold), the hallmarks of AD, with a significant upsurge in the ACh hydrolyzing enzyme, AChE by 2.1-fold, in comparison with the SO group (for AChE: F(3, 20) = 2.054, p = 0.1386; for Tau: F(3, 16) = 3.105, p = 0.0562; for Aβ42: F(3, 20) = 4.235, p = 0.0180). The gene discussed is MAPT; the disease is Alzheimer disease.