The current study demonstrates the neuroprotective and memory-enhancing capacity of E. bonariensis extract in the OVX/D-Gal rat model of AD through increasing α7-nAChRs expression and modulating Jak2/STAT3/NF-ĸB p65 and PI3K/AKT signaling cascades. The gene discussed is AKT1; the disease is Alzheimer disease.