Zhang et al. found that probucol, as a cholesterol-lowering drug with strong antioxidant properties, improved EMT and pulmonary fibrosis by restoring SIRT3 expression [118].In addition, a recent study found that baicalein attenuates bleomycin-induced lung fibroblast senescence and pulmonary fibrosis by restoring SIRT3 expression and inhibiting TGF-β1/Smad signaling pathway [36]. This evidence concerns the gene SIRT3 and pulmonary fibrosis.