TGFB1 and renal fibrosis: Studies have found that Yishen Tongluo formula significantly improves renal fibrosis by regulating SIRT6/TGF-β1/Smad2/3 signaling pathway, promoting TGF-β1 degradation, and then inhibiting the expression of type I collagen, α-smooth muscle actin, type IV collagen and fibronectin [122].