HOTAIR binds to lysine-specific histone demethylase 1A (KDM1A) and polycomb repressive complex 2 (EZH2) in the 5′ and 3′ regions, repressing the transcription of the homeobox D cluster (HOXD) family genes in the progression of breast cancer and CRC. The gene discussed is EZH2; the disease is colorectal carcinoma.