CCND1 and colorectal carcinoma: The effects of RP11-468E2.5 decrease on the activation of the JAK/STAT signaling pathway, which is driven by the induce of STAT5 and STAT6, elevating cell proliferation and inhibiting apoptosis in CRC, are also highlighted by the fact that silencing of RP11-468E2.5 results in an increase in the expressions of JAK2, STAT3, STAT5, STAT6, CCND1, and Bcl-2 [73].