Silencing lncRNA LINC00152-1 dramatically reduces the expression of p-ERK-1/2 and p-MEK-1/2 in GC cells while having no effect on the expression of total ERK-1/2 and MEK-1/2, demonstrating the significance of LINC00152-1 in promoting the MAPK signaling pathway [30]. This evidence concerns the gene MAPK3 and gastric cancer.