From the cell death assay (Figure 8G), EDU proliferation assay (Figure 8H) and cell cycle assay (Figure 8I), The results showed that that knockdown of STAT4 decreased the proliferative capacity and cell viability of HL-60 cells, and caused cell cycle changes.These results indicated that STAT4 was up-regulated in AML and associated with a poor prognosis, STAT4 promoted AML cells growth. Here, STAT4 is linked to acute myeloid leukemia.