The avoidance or minimization of the interference at the mesentery level would allow CQ to effectively sabotage the autophagic survival signaling triggered by the intracellular 2‐DG and its HK2‐driven nonmetabolizable end product 2‐DG‐6‐P, in the HK2‐addicted cancer cells to drive the observed synergistic apoptosis. Here, HK2 is linked to cancer.