Although the sample size in this studywas small, the results provide evidence that PROSER2 expression patternsmay vary depending on the stage of the disease and also provide functionalrelevance through overexpression and knockdown at the cellular level.Furthermore, the analysis of binding partners of PROSER2, STK25, andPDCD10 revealed the potential mechanisms involved in the progressionof pancreatic cancer, closely related to cell proliferation and migration. This evidence concerns the gene STK25 and pancreatic neoplasm.