Among the downregulated proteins in PROSER2-overexpressingcells, TYMS and S100A6 are highly expressed in breast, gastric, andliver cancer, and in lymph node metastatic tissues, suggesting theirpotential as biomarkers for cancer metastasis.30,31 Furthermore, FAM20C is a marker for tumor progression in gliomaand may promote metastasis in triple-negative breast cancer throughthe phosphorylation of target proteins.32−34 Therefore, PROSER2 mayfunction as a tumor suppressor protein in PDAC. This evidence concerns the gene S100A6 and cancer.