Moreover, high PROSER2 expressionhas been reported to promote cancer cell metastasis in osteosarcoma.21 However, in this study, a contrasting patternwas observed with no or minimal expression of PROSER2 in advanced-stagepancreatic cancer (GPDOXc), and knockdown of PROSER2 in cells withhigh expression led to a significant increase in the growth and metastaticcapability of cancer cells (Figure 2). This evidence concerns the gene PROSER2 and cancer.