This inhibition prevents the activation of cellular signals related to angiogenesis (e.g., Ras/Rac, mitogen-activated protein kinase [MEK]/extracellular signal-regulated kinase [ERK], phosphoinositide 3-kinase [PI3K]/protein kinase B [AKT], and phospholipase C gamma 1 [PLCG1]) that are responsible for cancer cell growth and proliferation. This evidence concerns the gene WNK2 and cancer.