They transfer onco-miRs as for example miR155, miR214, miR21 (Zonari et al., 2013; Feng and Tsao, 2016; Abels et al., 2019; Yang et al., 2019; Xu et al., 2021; Orso et al., 2023) or tumorigenic transcription factors (such as Stat3) into tissue-resident microglia, infiltrating myeloid-derived macrophages (Gabrusiewicz et al., 2018; Johnson et al., 2018; Xu et al., 2021) and tumor-infiltrating regulatory T cells (Li et al., 2017). The gene discussed is STAT3; the disease is neoplasm.