STAT3 and central nervous system cancer: If the glioma is highly invasive (i.e., LN229 glioma cell line), astrocytes increase the migratory capacity of tumor cells by inducing over-expression of genes related to migratory signaling pathways, such as STAT3 (signal transducer and activator of transcription) and HGF/MET (hepatocyte growth factor/mesenchymal-epithelial transition factor) (Cui et al., 2023).