SCN2A and autism: Therefore, we generated induced pluripotent stem cells (iPSCs) from an ASD individual harboring an SCN2A+/R607* variant and their sex-matched parental control, recruited from the Autism Speaks MSSNG project.1 Further, there is incomplete penetrance of seizure phenotypes in SCN2A patients and that some heterozygous models may not recapitulate clinical observations (Ogiwara et al., 2018; Sanders et al., 2018; Fallah and Eubanks, 2020).