FANCD2 and Alzheimer disease: The E2 treatment for short time period, 15 min, significantly increased both of the frequency (Spikes/Min) and amplitude (ΔF/F0) of Ca2+ oscillations in all neurons from both male and female donors, and non-AD and AD donors except for the frequency of FAD2 and SAD2 (Fig. 4B) (Supplementary Video 1) (Supplementary Fig. 3A).