TNF and neoplasm: These proteins are essential for apoptosis (Bcl-xL, Bcl-2, c-IAP1, Mcl-1, c-IAP2, XIAP), the cell cycle (cdc-25, cyclins D1, B1 and A1), anti-tumor (ADAM10, HSP70, p21, Myc, RNA polymerase, p27) and inflammatory activities and immuno-regulation (TNF-a, IL-1, IL-4, IFN-a, IL-6, IL-2, CD80, CD40) [88].