To evaluate the potential clinical relevance of the selected candidate genes that are conserved in humans, we took advantage of the UK biobank and demonstrated that variants in the human GFM1 and RICTOR genes were associated with several age-related and metabolic diseases, including heart disease, dementia, diabetes, renal failure, liver disease, all of which contribute to shorter life expectancy due to their detrimental effects on cardiac, metabolic and overall health and organ function. This evidence concerns the gene RICTOR and kidney failure.