Since ACE-2 receptors contribute to lowering oxidative stress which in turn modulates the binding affinity of both SARS-CoV-2 S protein and ACE-2, the authors concluded that, therapeutics that reduce oxidative stress could prevent viral binding to host cells and have a beneficial effect in the early stage of viral infection (Suhail et al., 2020). This evidence concerns the gene ACE2 and viral infectious disease.