P. anisum and its phytochemicals may act directly on the viral infection by inhibiting SARS-CoV-2 S protein and 3CLPRO, and could intervene in the COVID-19 pathological process through their anti-inflammatory, antioxidant and hepatoprotective properties, balancing COVID-19-associated dysbiosis, supporting the gut barrier, and promoting a dual therapeutic action in the respiratory and GI systems via the gut-lung axis. Here, PROS1 is linked to COVID-19.