GPX4 and neoplasm: Previous studies have demonstrated that various plant metabolites such as ursolic acid, oleanolic acid, Jiyuan oridonin A (JDA), Cucurbitacin B (CuB), Brucine, Pseudolaric acid B (PAB), Ginkgetin, β-elemene, and et al. can induce ferroptosis by intervening in the GSH/GPX4 pathway and then inhibit tumor growth (Wang et al., 2018; Chen et al., 2020a; Gao et al., 2020; Huang et al., 2021; Liu et al., 2021; Lou et al., 2021; Lu et al., 2021).