A study by Xie et al. demonstrated that robustaflavone, isolated from Selaginella trichoclada, triggered iron-dependent cell death in breast cancer cells by enhancing the expression of voltage-dependent anion channel 2 (VDAC2) and downregulating Nedd4 E3 ubiquitin ligase, resulting in the generation of lipid peroxidation and ROS (Xie et al., 2021). This evidence concerns the gene VDAC2 and breast cancer.