Moreover, CellChat analysis unveiled ligand-receptor pairs mediating communication between tumor epithelial cells and disulfidptosis-related TME subgroups, such as TNFSF12-TNFRSF12A, TNF-TNFRSF1A, OSM-(OSMR+IL6ST), OSM-(LIFR+IL6ST), HBEGF-EGFR, and EREG-EGFR. The gene discussed is TNFRSF12A; the disease is neoplasm.