Through cellchat analysis, we aimed to elucidate the comprehensive ligand-receptor interactions between disulfidptosis-mediated TME subgroups and tumor epithelial cells, involving various signaling pairs such as TNFSF12-TNFRSF12A, TNF-TNFRSF1A, OSM-(OSMR+IL6ST), OSM-(LIFR+IL6ST), HBEGF-EGFR, and EREG-EGFR. The gene discussed is TNFRSF12A; the disease is neoplasm.