Furthermore, Th1 polarization correlated with leptin, an adipokine associated with obesity-mediated inflammation, and IL-6, a cytokine downstream in the leptin inflammatory pathway, suggesting that obesity was driving the Th1 systemic inflammation in obese children with asthma (Rastogi et al., 2012). The gene discussed is LEP; the disease is obesity due to melanocortin 4 receptor deficiency.