Studies found that macrophages can cause inflammation in obese mice, causing macrophages to secrete interleukin-1 (IL-1), induction of type 3 innate lymphocyte activation, and secretion of interleukin-17A (Interleukin-17A, IL-17A) to induce AHR and airway inflammation, which is the key mechanism of obesity-related asthma. The gene discussed is IL1B; the disease is obesity disorder.