However, the distribution and specific mechanisms of orexin and its receptors in PMS/PMDD have not been fully elucidated and may be related to the interaction of orexin with neurotransmitters, such as 5-HT, noradrenaline, acetyl-choline, GABA, and dopamine, etc. Large-scale preclinical and clinical trials are needed to further explore the relevant mechanisms. Here, HCRT is linked to premenstrual tension.