KEGG pathway analysis showed that the candidate genes were mainly enriched in virion-herpesvirus, Th1 and Th2 cell differentiation, inflammatory bowel disease, Th17 cell differentiation, T-cell receptor signaling pathway, PD-L1/PD-1 checkpoint pathway in cancer, Toll-like receptor signaling pathway, necroptosis, natural killer cell mediated cytotoxicity, and NOD-like receptor signaling pathway (Figure 3A) (Supplementary Table 3). The gene discussed is CD274; the disease is cancer.