INS and Hypoglycemia: However, given that in our experiments even the most potent concentration of Ex-4 in 6 mM glucose could only elicit a [Ca2+]IC response in approximately a quarter of beta cells within an islet, and that these [Ca2+]IC elevations were transient in nature (Figure 1B), it is improbable that this could contribute to a substantial insulin secretion capable of triggering a potentially life-threatening hypoglycaemia.