The extent of increase in HK2 protein by stabilization to proteolysis in hyperglycemia depends on: (i) the increase in cellular glucose concentration such that glucose competes effectively with HSC70 at the C-terminal active of HK2 and (ii) the duration of increased glucose concentration with respect to the in situ half-life t1/2 of HK2 protein. This evidence concerns the gene HK2 and Hyperglycemia.