Overexpression of GLUT1 and overexpression of HK2 (with HFD feeding) produces insulin resistance—increasing HK2-linked unscheduled glycolysis in the fasting state. HK2(+/−) mice had lower plasma glucose and insulin concentrations, compared to WT controls in glucose tolerance test—decreasing HK2-linked unscheduled glycolysis. The gene discussed is SLC2A1; the disease is Insulin resistance.