This may indicate that clinical HK2-linked unscheduled glycolysis is exacerbated by variability in hyperglycemia, with glycolytic intermediates accumulating most markedly with increased plasma glucose concentration after a period of lower glucose exposure and low level G6P/Mondo A/Mlx transcriptional signaling with low basal expression of glycolytic enzymes. This evidence concerns the gene HK1 and Hyperglycemia.