This ultimately leads to theER and mitochondrial stress due to an increase in calcium influx.20,21 Mutant SOD1 has been shown to impair the expression of monocarboxylatetransporter 1 (MCT1) in oligodendrocytes, which delivers the energymetabolite lactate to the axon, thereby causing a reduced supply ofenergy to the motor neuron.22 Overall,these findings suggest that ALS propagates through a noncell autonomousfashion rather than damage to neurons alone. The gene discussed is SOD1; the disease is amyotrophic lateral sclerosis.