SOD1 and amyotrophic lateral sclerosis: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerativedisease with no cure, and current treatment options are very limited.Previously, we performed a high-throughput screen to identify smallmolecules that inhibit protein aggregation caused by a mutation inthe gene that encodes superoxide dismutase 1 (SOD1), which is responsiblefor about 25% of familial ALS.