Acylglycerol kinase (AGK) positively regulates PTEN (phosphatase and tensin homolog) phosphorylation and inhibits PTEN’s phosphatase activity in CD8+ T cells when PTEN accumulates on the plasma membrane through the mediation of TCR and CD28, promoting activation of PI3K-mTOR modulating glycolysis, and controlling anti-tumor activity (82). This evidence concerns the gene PTEN and neoplasm.