For example, using this approach, the researchers revealed the global epigenomic information loss that occurs with H3K27ac histone modifications in patients with advanced AD; Runt-associated transcription factor 1, Spi-1 Proto-Oncogene and other transcription factors play an important role in the pathogenesis of microglia AD (Xiong et al., 2023). This evidence concerns the gene SPI1 and Alzheimer disease.