It is worth noting that MRT’s are mostly classified as MYC subgroups although not exclusively, with 1 study reporting 85% of the extra-CNS MRT using the methylation array platform.17 This preferential subgroup bias by tumor location is consistent with previous research on human ATRT where SHH was suspected to be of neural-origin and MYC was suspected to be of mesenchymal-origin.4,11. The gene discussed is SHH; the disease is neoplasm.