Case 2 harbored variant Ile429Val that originated from his mother with febrile seizures and located in PDZ3 of MPDZ, which interacts with DAPLE (encoded by CCDC88C) that is potentially associated with neurodegenerative diseases, congenital, hydrocephalus, and epilepsy in an autosomal dominant/recessive inheritance.3 This evidence concerns the gene CCDC88C and epilepsy.