In A549 cells with a viral infection, IL6 was up-regulated (log2FC = 0.968) and MAF was down-regulated (log2FC = −0.68); opposite regulation in AR-enzalutamide and siRNA-inhibited A549 cells was also found, suggesting that MAF could be a co-regulatory partner with AR independently in the induction of IL6 expression. Here, MAF is linked to viral infectious disease.