Besides, FGF21 also participated in various chronic liver diseases including chronic liver injury,41, 42, 43, 44, 45, 46 alcoholic liver disease,47 hepatocellular carcinoma,48, 49, 50 α1-antitrypsin (α1AT)-related liver disease,51,52 Wilson's disease,53 and viral hepatitis54,55 and was reported to play different roles depending on disease and cell (Table 1). This evidence concerns the gene FGF21 and hepatocellular carcinoma.