Besides, FGF21 also participated in various chronic liver diseases including chronic liver injury,41, 42, 43, 44, 45, 46 alcoholic liver disease,47 hepatocellular carcinoma,48, 49, 50 α1-antitrypsin (α1AT)-related liver disease,51,52 Wilson's disease,53 and viral hepatitis54,55 and was reported to play different roles depending on disease and cell (Table 1). Here, FGF21 is linked to liver disorder.