A fascinating fact that we highlight in this review is that the lncRNA PVT1 is part of several gene fusions with mRNAs in numerous types of cancer, from leukemias to solid tumors such as breast, lung, prostate, esophagus, medulloblastoma, ovarian, stomach and uterine cancer (Table 1). The gene discussed is PVT1; the disease is medulloblastoma.