Of all the fusion lncRNAs we described in the previous section, it is really exciting to appreciate all the fusions in which PVT1 is involved, as it reminds us of the famous EML4–ALK gene fusion detected in anaplastic lymphoma and non-small cell lung cancer; despite its low prevalence, there are several drugs to inhibit its kinase activity, thus representing a watershed in therapeutics.108. This evidence concerns the gene ALK and non-small cell lung carcinoma.