It mediates the overexpression of E26 transformation-specific family transcription factors in response to androgen, and thus, it aberrantly activates downstream oncogenes that play important roles in many biological processes, including cell proliferation, angiogenesis, and invasiveness.40, 41, 42 FGFR3–TACC3, in glioblastoma, is an example of tandem duplication generating a fusion protein that leads to the constitutively activated kinase signaling of FGFR3, and thereby, promotes cell proliferation and tumor progression.43 This evidence concerns the gene FGFR3 and glioblastoma.