AMPK is a key regulator of cellular metabolism, and its deregulation is linked to metabolic diseases such as obesity, diabetes, inflammation, and cancer.1, 2, 3 As a protein kinase complex, AMPK activates catabolic processes and inhibits anabolic processes to balance cellular energy, impacting gene transcription, signaling transduction, and cellular fate. This evidence concerns the gene PRKAA2 and obesity disorder.