Although studies in keratinocytes and colonic myofibroblasts have shown that IL-22 activates the release of anti-microbial proteins, acute-phase proteins, inflammatory cytokines, and chemokines [[38], [39], [40]], others have found that IL-22 also exhibits anti-inflammatory roles by protecting hepatocytes from damage during acute liver inflammation [41,42]. The gene discussed is DDAH2; the disease is Acute hepatitis.